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How can FODZYME® be used to help patients with IBS and other GI conditions, such as Gastroesophageal reflux disease (GERD), diverticulitis and Inflammatory bowel disease (IBD)?Updated 9 months ago

FODZYME® breaks down the FODMAPs in food; it is not intended to diagnose, treat, cure, or prevent any disease.

There is a small body of research to indicate that FODMAPs may contribute to symptoms in those with both IBS and GERD and anywhere from 50% to 86% of those with IBS alone respond to a low FODMAP diet [1,2]. Research on the relationship between FODMAPs and both active and inactive IBD is also limited, though some findings do point towards a potential relationship between FODMAPs and inflammation, especially if symptoms persist while in remission [3,4,5]. Temporary lactose intolerance can also occur secondary to inflammatory conditions, such as IBD [6].

A low-fiber diet can be a risk factor for some GI conditions [7]. If FODMAP sensitivities are leading to limited fruit, vegetable and whole grain intake, FODZYME® can be a helpful tool to add more fiber into the diet and reduce reliance on processed foods.

FODZYME® dose and administration for patients who have concurrent GI conditions is the same as for those who have FODMAP-sensitivities alone. Our elegant formula consists of simply the digestive enzymes (proteins) and a minor amount of dextrin as stabilizer, which means it is free of potential gut irritants that are often present in other over-the-counter products.

There is nothing to indicate FODZYME® is unsafe in those with multiple GI conditions. Many patients with IBD and other GI conditions have seen success using FODZYME® as part of a holistic treatment plan. See our additional FAQ Are there any contraindications or side effects? if you would like to read more.


  1. Plaidum S, Patcharatrakul T, Promjampa W, Gonlachanvit S. The Effect of Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAP) Meals on Transient Lower Esophageal Relaxations (TLESR) in Gastroesophageal Reflux Disease (GERD) Patients with Overlapping Irritable Bowel Syndrome (IBS). Nutrients. 2022;14(9):1755. Published 2022 Apr 22. doi:10.3390/nu14091755

  2. Hill P, Muir JG, Gibson PR. Controversies and Recent Developments of the Low-FODMAP Diet. Gastroenterol Hepatol (N Y). 2017;13(1):36-45.

  3. Cox SR, Clarke H, O'Keeffe M, et al. Nutrient, Fibre, and FODMAP Intakes and Food-related Quality of Life in Patients with Inflammatory Bowel Disease, and Their Relationship with Gastrointestinal Symptoms of Differing Aetiologies. J Crohns Colitis. 2021;15(12):2041-2053. doi:10.1093/ecco-jcc/jjab116

  4. Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM, Whelan K. Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial. Gastroenterology. 2020 Jan;158(1):176-188.e7. doi: 10.1053/j.gastro.2019.09.024. Epub 2019 Oct 2.

  5. Bodini G, Zanella C, Crespi M, Lo Pumo S, Demarzo MG, Savarino E, Savarino V, Giannini EG. A randomized, 6-wk trial of a low FODMAP diet in patients with inflammatory bowel disease. Nutrition. 2019 Nov-Dec;67-68:110542. doi: 10.1016/j.nut.2019.06.023. Epub 2019 Jul 1.

  6. Ratajczak AE, Rychter AM, Zawada A, Dobrowolska A, Krela-Kaźmierczak I. Lactose intolerance in patients with inflammatory bowel diseases and dietary management in prevention of osteoporosis. Nutrition. 2021;82:111043. doi:10.1016/j.nut.2020.111043

  7. Di Rosa C, Altomare A, Imperia E, Spiezia C, Khazrai YM, Guarino MPL. The Role of Dietary Fibers in the Management of IBD Symptoms. Nutrients. 2022;14(22):4775. Published 2022 Nov 11. doi:10.3390/nu14224775

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