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Is FODZYME safe for those who have gallbladder conditions or have had a gallbladder removal? Can FODZYME help digestive distress following gallbladder removal?Updated 9 months ago

The gallbladder is responsible for the concentration, storage and excretion of bile, which is involved in the digestion of fats (bile itself is made in the liver). There is also increasing evidence that bile is involved in the immune response and supports integrity of the intestinal mucosa. For this reason, there is a high overlap in the prevalence of gallbladder diseases and irritable bowel syndrome (IBS) or IBS-like symptoms [1].

Following gallbladder removal, bile is secreted directly by the liver into the intestine. Gastritis secondary to reflux of bile acids can occur following gallbladder removal and some research indicates that the addition of dietary soluble fiber can help manage reflux symptoms by binding bile in the stomach between meals [2,3]. Food tolerances vary following gallbladder removal, though flatulence and bloating are often reported with the consumption of gas-forming foods (beans, broccoli, Brussels sprouts, cabbage, cauliflower, garlic, legumes, and onions). [2] Bile acid malabsorption may also occur in a small portion of people following gallbladder removal and can result in bile acid diarrhea, which is treated with prescription medication [4].

There are no contraindications to using FODZYME with FODMAP-containing foods in those who have had gallbladder removal. However and as a precaution, we always recommend consulting with a healthcare provider before incorporating any new supplements into your daily routine.

From a preventative standpoint, there is also evidence that a low-fiber diet increases risk for diseases of the gallbladder. If FODMAP sensitivities are limiting your fiber intake, FODZYME may be a helpful tool to increase intake and variety of fiber-rich plant foods [5].

  1. de Jong JJ, Latenstein CSS, Boerma D, et al. Functional Dyspepsia and Irritable Bowel Syndrome are Highly Prevalent in Patients With Gallstones and Are Negatively Associated With Outcomes After Cholecystectomy: A Prospective, Multicenter, Observational Study (PERFECT - Trial). Ann Surg. 2022;275(6):e766-e772.

  2. Marcason W. What medical nutrition therapy guideline is recommended post-cholecystectomy?. J Acad Nutr Diet. 2014;114(7):1136. doi:10.1016/j.jand.2014.05.009

  3. Shin Y, Choi D, Lee KG, Choi HS, Park Y. Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease. Korean J Intern Med. 2018;33(4):829-836. doi:10.3904/kjim.2016.223

  4. Camilleri M. Bile Acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver. 2015;9(3):332-339. doi:10.5009/gnl14397

  5. Tehrani AN, Saadati S, Yari Z, et al. Dietary fiber intake and risk of gallstone: a case-control study. BMC Gastroenterol. 2023;23(1):119. Published 2023 Apr 11. doi:10.1186/s12876-023-02752-0

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