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Can FODZYME be used for Small Intestinal Bacterial Overgrowth (SIBO)?Updated 2 months ago

FODZYME is for those who are sensitive to foods that contain fructan, GOS, and lactose.

FODZYME does not target specific conditions — rather, FODZYME's enzymes break down the FODMAPs fructan, galacto-oligosaccharides (GOS), and lactose.

Small Intestinal Bacterial Overgrowth (SIBO) is a condition where excessive amounts of bacteria are present in the small intestine. Impaired gut motility, commonly present with irritable bowel syndrome (IBS), increases risk for SIBO and there is a high overlap in the two conditions. In fact, as many as 1/3 of those with IBS may have SIBO [1,2], though variations in SIBO testing and diagnostic methods mean data on the overlap is heterogeneous [3].

Treatment for SIBO includes addressing the underlying cause, induction of remission through antibiotics or antimicrobials and maintenance of remission. Diet and lifestyle modifications for SIBO aim to promote intestinal sterility and motility.

There is no one diet prescription for SIBO and the least restrictive, most nutrient-rich diverse diet is generally recommended. For those with bloating and diarrhea related to FODMAP intake, there is evidence to suggest that dietary restriction of FODMAPs may support symptom control [4].

The literature also supports inclusion of fiber-rich foods to support restoration of the microbiome during and following SIBO treatment. Excessive dietary restriction, such as a strict low FODMAP approach, may lower fiber intake if not implemented properly. This reduced fiber intake may promote a negative shift in the gut microbiota and deepen existing dysbiosis in those with SIBO [5].

FODZYME can help control symptoms related to FODMAP intake while promoting dietary diversity and abundance. Using FODZYME with FODMAP triggers enables a less restrictive, plant-based and fiber-rich diet.


  1. Ghoshal UC, Nehra A, Mathur A, Rai S. A meta-analysis on small intestinal bacterial overgrowth in patients with different subtypes of irritable bowel syndrome. J Gastroenterol Hepatol. 2020;35(6):922-931. doi:10.1111/jgh.14938
  2. Chen B, Kim JJ, Zhang Y, Du L, Dai N. Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systematic review and meta-analysis. J Gastroenterol. 2018;53(7):807-818. doi:10.1007/s00535-018-1476-9
  3. Shah A, Talley NJ, Jones M, et al. Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. Am J Gastroenterol. 2020;115(2):190-201. doi:10.14309/ajg.0000000000000504
  4. Patcharatrakul T, Juntrapirat A, Lakananurak N, Gonlachanvit S. Effect of Structural Individual Low-FODMAP Dietary Advice vs. Brief Advice on a Commonly Recommended Diet on IBS Symptoms and Intestinal Gas Production. Nutrients. 2019;11(12):2856. Published 2019 Nov 21. doi:10.3390/nu11122856
  5. Wielgosz-Grochowska JP, Domanski N, Drywień ME. Efficacy of an Irritable Bowel Syndrome Diet in the Treatment of Small Intestinal Bacterial Overgrowth: A Narrative Review. Nutrients. 2022;14(16):3382. Published 2022 Aug 17. doi:10.3390/nu14163382

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